same receptor two routes cambridge team maps the brain circuits behind obesity drugs Here is a puzzle that has nagged metabolism researchers for years: two obesity drugs hit the same receptor in completely opposite ways, and patients lose weight either way. A mouse study out of Cambridge has now supplied an answer, and it is not that one drug wins the tug-of-war. The two classes were never competing for the same target — they operate in different parts of the brain.

Same receptor, two routes: Cambridge team maps the brain circuits behind obesity drugs

READ MORE
simpsons hit run revival hinted at by matt groening then walked back on stage One word from Matt Selman at D23 landed less like a joke and more like damage control.

Simpsons: Hit & Run revival hinted at by Matt Groening — then walked back on stage

READ MORE
nvidia halves its openai backstop to 120b as anthropics revenue laughs off the bubble chatter The original figure Nvidia was expected to stand behind was $250 billion. The Wall Street Journal reports that the chipmaker is now willing to guarantee a little under $120 billion, a retreat that followed investor complaints about the scale of risk the company was absorbing.

Nvidia halves its OpenAI backstop to $120B as Anthropic’s revenue laughs off the bubble chatter

READ MORE
etherealize ceo vivek raman wall streets private chain comeback is a race to the bottom Vivek Raman has seen this film once already, and he's not expecting the sequel to have a different ending.

Etherealize CEO Vivek Raman: Wall Street’s private chain comeback is a ‘race to the bottom’

READ MORE
ranked the 10 best serial killer thrillers of all time For most of The Silence of the Lambs, Anthony Hopkins is stuck behind a pane of glass — and he still steals the entire film.

Ranked: The 10 Best Serial Killer Thrillers of All Time

READ MORE
mandalorian fans get a double drop on disney this september Two separate Mandalorian projects arrive on the very same day this September, and you won't need a movie ticket for either one.

Mandalorian Fans Get A Double Drop On Disney+ This September

READ MORE
clarity act stumbles strategy trims again and the fight nobody saw behind mastercards 1 8 billion bvnk buy Glassnode data shows roughly 210,000 bitcoin exited long-term holder wallets over the past week. It was the biggest movement of its kind since December 2024, and the standard reading would be a market top.

Clarity Act stumbles, Strategy trims again, and the fight nobody saw behind Mastercard’s $1.8 billion BVNK buy

READ MORE
seven years dark inside moscows bitcoin mining shutdown Bitcoin miners in Moscow have been ordered to power down their machines — and this is no temporary pause. Crypto mining is barred in the city, the wider Moscow Region and parts of Kursk all the way through Dec. 31, 2032.

Seven Years Dark: Inside Moscow’s Bitcoin Mining Shutdown

READ MORE
kingdom hearts 4 stops teasing d23 panel delivers the full extended trailer Mickey Mouse is now capable of folding himself flat like a sheet of paper.

Kingdom Hearts 4 Stops Teasing: D23 Panel Delivers the Full Extended Trailer

READ MORE
ai written books are swamping amazon and human authors earnings are paying the price For anyone earning a living with words, one figure stands out: from the first quarter of 2023 to the first quarter of 2026, Amazon's self-published catalog expanded 38.3 times over. Revenue, meanwhile, rose just 8.9 times.

AI-Written Books Are Swamping Amazon — and Human Authors’ Earnings Are Paying the Price

READ MORE